Fundamental Tenet of The Science of Toxicology
Order ID 53003233773 Type Essay Writer Level Masters Style APA Sources/References 4 Perfect Number of Pages to Order 5-10 Pages
Fundamental Tenet of The Science of Toxicology
Unit VI: Case Study
Animal use in toxicity testing has long been a controversial issue, however, there can be benefits. Read “The Use of
Animals in Research,” which is an article that can be retrieved from
Evaluate the current policies outlined in the Position Statement. Use the instructions to guide you in your analysis. Feel
free to use additional information and avenues of information, including the textbook, to critically analyze this policy.
In addition, answer the following questions:
How do toxicologists determine which exposures may cause adverse health effects?
How does the information apply to what you are learning in the course?
What were the objectives of this toxicity testing?
What were the endpoints of this toxicity testing?
Finally, include weather or not you agree with the Society of Toxicology’s position on animal testing.
Your Case Study assignment should be three to four pages in length. Use APA style guidelines in writing this assignment,
following APA rules for formatting, quoting, paraphrasing, citing, and referencing.
Animals in Research
The Importance of Animals in the Science
Research involving laboratory animals is important to people and to our quality of life. In the past century, most inhabitants of this planet have experienced an unprecedented rise in living standards, life expectancy and personal opportunity, in large part due to the many ways chemicals have been put to work for us. For example, drugs whose effects range from curing previously fatal bacterial infections, reducing the impact of AIDS, minimizing heart disease, decreasing age- related wrinkles, to reducing hair loss are widely available today.
The many benefits of the diverse uses of our natural resources are an outcome of careful scientific research and of using chemicals in an appropriate and safe manner. Toxicologists, the scientists who help determine the limits for safe use of materials, use modern technological research methods, including tests on animals, to protect human and animal health and the environment.
What is toxicology? Toxicology is the study of how chemical substances interact with living systems and affect normal processes, and the use of this information to predict safe exposure levels. Toxicological research and testing helps us to live safely and to derive benefit from natural and synthetic substances while avoiding harm. Toxicologists are involved in the evaluation of household products, medicines and the effects of incidental and occupational exposure to natural and manufactured substances. Toxicology also helps us develop the best treatments in the event that accidental overexposure does occur.
What is safe? Toxicologists know that no substance is risk-free. One fundamental tenet of the science of toxicology
is that all chemicals can cause harm at some level of exposure, summed up in the phrase “the dose makes the poison.” This means that exposure to a specific small amount of any substance will have no detectable impact on normal biological processes and is considered safe. Some doses actually have beneficial effects, as we all know from use of medicines. But increasing exposure to most substances will, at some point, cause harmful effects. Substances are considered toxic at that level. For example, digitalis is a plant product that has been used with great benefit to treat heart irregularities, but too large a dose will cause death. Oxygen provides another example of how increasing the dose can turn a safe compound into a toxic one. Oxygen is essential to life and part of the air we breathe, but when given at high concentrations it can cause lung and eye damage in infants.
Sometimes the possible negative effects of a substance are outweighed by the positive benefits at that dose. Dogs are treated with heartworm medication because the risk of death from heartworms is much greater than the risk of toxicity of the medication. Similarly, chemotherapeutic agents are used to destroy cancerous cells even though they may damage healthy cells in the process.
Prior to the use of new substances, toxicologists and policy makers are responsible for determining the range of exposure that is safe and the level of exposure that may be harmful to human health or to the environment. The effect of the level of exposure is also important when toxicologists assess the risk caused by a substance already present in the environment. The benefits of using a new substance, or the costs of removing an environmental contaminant, are viewed relative to the perception of what is safe.
The Importance of Animals in Research • Society of Toxicology • Research involving laboratory animals is necessary to ensure and enhance human and animal health and protection of the environment.
In the absence of human data, research with experimental animals is the most reliable means of detecting important toxic properties of chemical substances and for estimating risks to human and environmental health.
Research animals must be used in a responsible manner.
Scientifically-valid research designed to reduce, refine or replace the need for laboratory animals is encouraged. SOT Animals in Research Public Policy Statement 1999
❛ Research involving laboratory animals is necessary to ensure and enhance human and animal health and protection of the environment. ❜ SOT Animals in Research Public Policy Statement
Fundamental Tenet of The Science of Toxicology
QUALITY OF RESPONSE NO RESPONSE POOR / UNSATISFACTORY SATISFACTORY GOOD EXCELLENT Content (worth a maximum of 50% of the total points) Zero points: Student failed to submit the final paper. 20 points out of 50: The essay illustrates poor understanding of the relevant material by failing to address or incorrectly addressing the relevant content; failing to identify or inaccurately explaining/defining key concepts/ideas; ignoring or incorrectly explaining key points/claims and the reasoning behind them; and/or incorrectly or inappropriately using terminology; and elements of the response are lacking. 30 points out of 50: The essay illustrates a rudimentary understanding of the relevant material by mentioning but not full explaining the relevant content; identifying some of the key concepts/ideas though failing to fully or accurately explain many of them; using terminology, though sometimes inaccurately or inappropriately; and/or incorporating some key claims/points but failing to explain the reasoning behind them or doing so inaccurately. Elements of the required response may also be lacking. 40 points out of 50: The essay illustrates solid understanding of the relevant material by correctly addressing most of the relevant content; identifying and explaining most of the key concepts/ideas; using correct terminology; explaining the reasoning behind most of the key points/claims; and/or where necessary or useful, substantiating some points with accurate examples. The answer is complete. 50 points: The essay illustrates exemplary understanding of the relevant material by thoroughly and correctly addressing the relevant content; identifying and explaining all of the key concepts/ideas; using correct terminology explaining the reasoning behind key points/claims and substantiating, as necessary/useful, points with several accurate and illuminating examples. No aspects of the required answer are missing. Use of Sources (worth a maximum of 20% of the total points). Zero points: Student failed to include citations and/or references. Or the student failed to submit a final paper. 5 out 20 points: Sources are seldom cited to support statements and/or format of citations are not recognizable as APA 6th Edition format. There are major errors in the formation of the references and citations. And/or there is a major reliance on highly questionable. The Student fails to provide an adequate synthesis of research collected for the paper. 10 out 20 points: References to scholarly sources are occasionally given; many statements seem unsubstantiated. Frequent errors in APA 6th Edition format, leaving the reader confused about the source of the information. There are significant errors of the formation in the references and citations. And/or there is a significant use of highly questionable sources. 15 out 20 points: Credible Scholarly sources are used effectively support claims and are, for the most part, clear and fairly represented. APA 6th Edition is used with only a few minor errors. There are minor errors in reference and/or citations. And/or there is some use of questionable sources. 20 points: Credible scholarly sources are used to give compelling evidence to support claims and are clearly and fairly represented. APA 6th Edition format is used accurately and consistently. The student uses above the maximum required references in the development of the assignment. 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The paper has slight errors within the paper. This can include small errors or omissions with the cover page, abstract, page number, and headers. There could be also slight formatting issues with the document spacing or the font Additionally the paper might slightly exceed or undershoot the specific number of required written pages for the assignment. 10 points: Student provides a high-caliber, formatted paper. This includes an APA 6th edition cover page, abstract, page number, headers and is double spaced in 12’ Times Roman Font. Additionally, the paper conforms to the specific number of required written pages and neither goes over or under the specified length of the paper.
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